Get instant relief from nasal congestion, stuffy nose, and sinus pressure with Vicks Sinex Severe Congestion. This decongestant nasal spray provides instant relief by targeting congestion where you need it most, your nose! Get all day or all night relief with 12-hour relief, non-drowsy sinus medicine. The active ingredient, oxymetazoline, is one of the best options for treating severe sinus symptoms caused by a cold or seasonal allergies. While it provides powerful relief, the ultra fine mist spray delivers relief gently.